| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transcription initiation factor TFIID subunit 1 [1381-1497] |
|---|
| Ligand | BDBM346517 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TAF1-BD1 TR-FRET Binding Assay |
|---|
| IC50 | 85.0±n/a nM |
|---|
| Citation |  Adler, M; Burdick, DJ; Crawford, T; Duplessis, M; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Tsui, VH; Wang, S Therapeutic compounds and uses thereof US Patent US10202378 Publication Date 2/12/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transcription initiation factor TFIID subunit 1 [1381-1497] |
|---|
| Name: | Transcription initiation factor TFIID subunit 1 [1381-1497] |
|---|
| Synonyms: | BA2R | CCG1 | CCGS | TAF1 | TAF1-BD1 | TAF1-BD1 (aa 1381-1497) | TAF1_HUMAN | TAF2A |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 25344.81 |
|---|
| Organism: | Homo sapiens (human) |
|---|
| Description: | P21675[1381-1497] |
|---|
| Residue: | 217 |
|---|
| Sequence: | PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP
SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD
DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH
KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIV
|
|
|
|---|
| BDBM346517 |
|---|
| n/a |
|---|
| Name | BDBM346517 |
|---|
| Synonyms: | US10202378, Example 121 | o-tolylmethyl 4-(3-hydroxy-3-methyl-but-1-ynyl)-2,6-dimethyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-3-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H24N2O4 |
|---|
| Mol. Mass. | 392.4477 |
|---|
| SMILES | Cc1[nH]c2c(c1C(=O)OCc1ccccc1C)c(cn(C)c2=O)C#CC(C)(C)O |
|---|
| Structure | 
|
|---|
Search and Browse
