| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 2 |
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| Ligand | BDBM65524 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorometric Ub-AMC Hydrolysis Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | >114000±n/a nM |
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| Comments | extracted |
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| Citation |  Ott, CA; Baljinnyam, B; Zakharov, AV; Jadhav, A; Simeonov, A; Zhuang, Z Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors. ACS Chem Biol12:2399-2407 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 2 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 2 |
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| Synonyms: | 41 kDa ubiquitin-specific protease | Deubiquitinating enzyme 2 | UBP2_HUMAN | UBP41 | USP2 | Ubiquitin thioesterase 2 | Ubiquitin-specific-processing protease 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68093.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103660 |
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| Residue: | 605 |
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| Sequence: | MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFL
TRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNN
CLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELC
TLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETG
KGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLY
MRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQE
FLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLK
SSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCR
GRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAV
YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELAS
PPSRM
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| BDBM65524 |
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| n/a |
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| Name | BDBM65524 |
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| Synonyms: | (-)-Aricine | Heterophylline (VAN) | Quinovatine |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N2O4 |
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| Mol. Mass. | 382.4528 |
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| SMILES | COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@@H]3C[C@H]12 |t:4| |
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| Structure | 
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