| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin-like modifier-activating enzyme 1 |
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| Ligand | BDBM329875 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Ubiquitin Activating Enzyme (UAE) HTRF Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent US10202389 Publication Date 2/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin-like modifier-activating enzyme 1 |
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| Name: | Ubiquitin-like modifier-activating enzyme 1 |
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| Synonyms: | A1S9T | UBA1 | UBA1_HUMAN | UBE1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117834.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_827630 |
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| Residue: | 1058 |
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| Sequence: | MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY
VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE
EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH
NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH
GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK
ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA
LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI
MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG
CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN
PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT
LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA
ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN
NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG
SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP
GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA
VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV
QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS
RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR
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| BDBM329875 |
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| n/a |
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| Name | BDBM329875 |
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| Synonyms: | (rac)-[(1R,2R,3S,4R)-4-{[2-(3-ethynylphenyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino}- | US10202389, Compound I-083 | US9663525, Compound I-083 | US9796725, Compound I-083 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N5O5S |
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| Mol. Mass. | 443.476 |
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| SMILES | NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(c2)C#C)[C@H](O)[C@@H]1O |r| |
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| Structure | 
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