| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 1 |
|---|
| Ligand | BDBM347485 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| IC50 | 0.900±n/a nM |
|---|
| Citation |  van Duzer, JH; Mazitschek, R Piperidine derivatives as HDAC1/2 inhibitors US Patent US9790180 Publication Date 10/17/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 1 |
|---|
| Name: | Histone deacetylase 1 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55090.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13547 |
|---|
| Residue: | 482 |
|---|
| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
|---|
| BDBM347485 |
|---|
| n/a |
|---|
| Name | BDBM347485 |
|---|
| Synonyms: | US9790180, ID 019 | US9790180, ID 020 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H31N5O3S |
|---|
| Mol. Mass. | 505.632 |
|---|
| SMILES | Nc1ccc(cc1NC(=O)c1ccc(NC2CCN(CC2)C(=O)N2CCOCC2)cc1)-c1cccs1 |
|---|
| Structure | 
|
|---|
Search and Browse
