| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 1 [1-424] |
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| Ligand | BDBM227719 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MKNK1 Kinase High ATP Assay |
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| pH | 7.5±n/a |
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| IC50 | 2±n/a nM |
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| Comments | extracted |
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| Citation |  Klar, U; Wortmann, L; Kettschau, G; Pühler, F; Lienau, P; Sülzle, D Substituted pyrazolopyrimidinylamino-indazoles US Patent US9556181 Publication Date 1/31/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| MAP kinase-interacting serine/threonine-protein kinase 1 [1-424] |
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| Name: | MAP kinase-interacting serine/threonine-protein kinase 1 [1-424] |
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| Synonyms: | MAP kinase signal-integrating kinase 1 (MKNK1) | MKNK1 | MKNK1_HUMAN | MNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47005.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-424 |
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| Residue: | 424 |
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| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEP
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| BDBM227719 |
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| n/a |
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| Name | BDBM227719 |
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| Synonyms: | 3-bromo-n-(6-methoxy-1h-indazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | US9556181, 10 | US9556181, 16 | US9556181, 4 | US9556181, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H10BrN7O |
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| Mol. Mass. | 360.169 |
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| SMILES | COc1cc2[nH]ncc2cc1Nc1ncnc2[nH]nc(Br)c12 |
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| Structure | 
|
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