| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 3-kinase regulatory subunit beta |
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| Ligand | BDBM350457 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Transcreener KINASE Assay |
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| IC50 | 630±n/a nM |
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| Citation |  Su, W; Dai, G; Zhang, W; Deng, W Imidazopyridazine compounds and their use US Patent US10208066 Publication Date 2/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 3-kinase regulatory subunit beta |
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| Name: | Phosphatidylinositol 3-kinase regulatory subunit beta |
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| Synonyms: | P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 81542.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00459 |
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| Residue: | 728 |
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| Sequence: | MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALG
PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
PGPPPAAR
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| BDBM350457 |
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| n/a |
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| Name | BDBM350457 |
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| Synonyms: | (S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyrimidine-4,6-diamine | US10208066, Compound 81 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18ClN9O |
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| Mol. Mass. | 447.88 |
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| SMILES | C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r| |
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| Structure | 
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