| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM16104 |
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| Substrate/Competitor | BDBM16100 |
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| Meas. Tech. | DHODH Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 4000±1000 nM |
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| Km | 6600±700 nM |
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| kcat | 15.4±0.2 1/sec |
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| Comments | Mixed inhibition. |
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| Citation |  Hurt, DE; Sutton, AE; Clardy, J Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg Med Chem Lett16:1610-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM16104 |
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| BDBM16100 |
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| Name | BDBM16104 |
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| Synonyms: | 3-[3-(4-tert-butylphenyl)phenyl]-5-carbamoylbenzoic acid | 4 -tert-butyl-5-carbamoyl-1,1 :3 ,1 -terphenyl-3-carboxylic acid | AMX01 | Brequinar-derived asymmetric terphenyl compound |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23NO3 |
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| Mol. Mass. | 373.4443 |
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| SMILES | CC(C)(C)c1ccc(cc1)-c1cccc(c1)-c1cc(cc(c1)C(O)=O)C(N)=O |
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| Structure | 
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