| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 3 |
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| Ligand | BDBM350908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Omnia Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Haq, N; Niu, D; Petter, RC; Qiao, L; Singh, J; Zhu, Z ERK inhibitors and uses thereof US Patent US9796700 Publication Date 10/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 3 |
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| Name: | Mitogen-activated protein kinase 3 |
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| Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 |
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| Type: | Protein |
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| Mol. Mass.: | 43136.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | curated by PDB 4QTB |
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| Residue: | 379 |
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| Sequence: | MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
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| BDBM350908 |
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| n/a |
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| Name | BDBM350908 |
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| Synonyms: | US9796700, Compound I-2 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F3N6O2 |
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| Mol. Mass. | 448.4415 |
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| SMILES | NC(=O)C1CCCC(C1)Nc1ncc(c(Nc2ccccc2NC(=O)C=C)n1)C(F)(F)F |
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| Structure | 
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