| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 2 |
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| Ligand | BDBM351407 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AlphaScreen Assay |
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| IC50 | <50±n/a nM |
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| Citation |  Rice, KD; Anand, NK; Bussenius, J; Costanzo, S; Kennedy, AR; Peto, CJ; Tsang, TH; Blazey, CM Substituted quinazolines as receptor-type kinase inhibitors US Patent US9796704 Publication Date 10/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 2 |
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| Name: | Ephrin type-A receptor 2 |
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| Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin receptor | Epithelial cell kinase | Tyrosine-protein kinase receptor ECK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108260.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1505248 |
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| Residue: | 976 |
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| Sequence: | MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMN
DMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFN
LYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGG
EEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPS
PEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDI
VYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG
LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSN
SYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGG
VAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQA
VLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF
LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGML
RGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIP
IRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM
DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSG
SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY
SLLGLKDQVNTVGIPI
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| BDBM351407 |
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| n/a |
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| Name | BDBM351407 |
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| Synonyms: | 1,4:3,6-dianhydro-5-O-[4-{[3-bromo-5- (trifluoromethyl)phenyl]amino}-6- (methyloxy)quinazolin-7-yl]-2-deoxy-2-fluoro- D-iditol | US9796704, Entry 127 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18BrF4N3O4 |
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| Mol. Mass. | 544.294 |
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| SMILES | COc1cc2c(Nc3cc(Br)cc(c3)C(F)(F)F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12 |r| |
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| Structure | 
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