| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 2 |
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| Ligand | BDBM351447 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AlphaScreen Assay |
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| IC50 | <50±n/a nM |
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| Citation |  Rice, KD; Anand, NK; Bussenius, J; Costanzo, S; Kennedy, AR; Peto, CJ; Tsang, TH; Blazey, CM Substituted quinazolines as receptor-type kinase inhibitors US Patent US9796704 Publication Date 10/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 2 |
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| Name: | Ephrin type-A receptor 2 |
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| Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin receptor | Epithelial cell kinase | Tyrosine-protein kinase receptor ECK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108260.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1505248 |
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| Residue: | 976 |
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| Sequence: | MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMN
DMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFN
LYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGG
EEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPS
PEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDI
VYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG
LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSN
SYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGG
VAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQA
VLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF
LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGML
RGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIP
IRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM
DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSG
SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY
SLLGLKDQVNTVGIPI
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| BDBM351447 |
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| n/a |
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| Name | BDBM351447 |
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| Synonyms: | N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({5- [4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3- yl}methyl)oxy]quinazolin-4-amine | US9796704, Entry 167 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H16Cl2F3N5O3 |
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| Mol. Mass. | 562.327 |
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| SMILES | COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1noc(n1)-c1ccc(cc1)C(F)(F)F |
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| Structure | 
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