Reaction Details |
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Target | Ephrin type-A receptor 2 |
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Ligand | BDBM351490 |
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Substrate/Competitor | n/a |
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Meas. Tech. | AlphaScreen Assay |
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IC50 | <50±n/a nM |
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Citation | Rice, KD; Anand, NK; Bussenius, J; Costanzo, S; Kennedy, AR; Peto, CJ; Tsang, TH; Blazey, CM Substituted quinazolines as receptor-type kinase inhibitors US Patent US9796704 Publication Date 10/24/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Ephrin type-A receptor 2 |
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Name: | Ephrin type-A receptor 2 |
Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin receptor | Epithelial cell kinase | Tyrosine-protein kinase receptor ECK |
Type: | PROTEIN |
Mol. Mass.: | 108260.70 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1505248 |
Residue: | 976 |
Sequence: | MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMN
DMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFN
LYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGG
EEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPS
PEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDI
VYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG
LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSN
SYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGG
VAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQA
VLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF
LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGML
RGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIP
IRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM
DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSG
SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY
SLLGLKDQVNTVGIPI
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BDBM351490 |
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n/a |
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Name | BDBM351490 |
Synonyms: | N-(3,4-dichlorophenyl)-7-[({4-[(4-methyl-1,4- diazepan-1-yl)methyl]-1,3-thiazol-2- yl}methyl)oxy]-6-(methyloxy)quinazolin-4- amine | US9796704, Entry 210 |
Type | Small organic molecule |
Emp. Form. | C26H28Cl2N6O2S |
Mol. Mass. | 559.511 |
SMILES | COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1nc(CN2CCCN(C)CC2)cs1 |
Structure |
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