| Reaction Details |
|---|
 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 2 |
|---|
| Ligand | BDBM329853 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | HTRF Assay |
|---|
| IC50 | <10±n/a nM |
|---|
| Citation |  Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent US9796725 Publication Date 10/24/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| SUMO-activating enzyme subunit 2 |
|---|
| Name: | SUMO-activating enzyme subunit 2 |
|---|
| Synonyms: | 6.3.2.- | Anthracycline-associated resistance ARX | SAE2 | SAE2_HUMAN | SUMO-activating enzyme subunit 2 | SUMO-activating enzyme subunit 2 (SAE2) | UBA2 | UBLE1B | Ubiquitin-like 1-activating enzyme E1B | Ubiquitin-like modifier-activating enzyme 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 71206.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UBT2 |
|---|
| Residue: | 640 |
|---|
| Sequence: | MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQ
FLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRA
ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS
EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRIST
KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ
NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN
LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK
QPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDV
QIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK
DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN
ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
|
|
|
|---|
| BDBM329853 |
|---|
| n/a |
|---|
| Name | BDBM329853 |
|---|
| Synonyms: | (rac)-((1R,2R,3S,4R)-4-((2-(Benzo[b]thiophen-4-yl)pyrazolo[1,5-a]pyrimidin-7- | US10202389, Compound I-061 | US9663525, Compound I-061 | US9796725, Compound I-061 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21N5O5S2 |
|---|
| Mol. Mass. | 475.541 |
|---|
| SMILES | NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc3sccc23)[C@H](O)[C@@H]1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
