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Target3-phosphoinositide-dependent protein kinase 1 [51-359]
LigandBDBM17054
Substrate/CompetitorPDKtide
Meas. Tech.PDK1 Kinase Activity Assay
pH7.5±n/a
Temperature303.15±n/a K
IC50 5±n/a nM
Citation Komander, D; Kular, GS; Bain, J; Elliott, M; Alessi, DR; Van Aalten, DM Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition. Biochem J375:255-62 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
3-phosphoinositide-dependent protein kinase 1 [51-359]
Name:3-phosphoinositide-dependent protein kinase 1 [51-359]
Synonyms:3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (aa 51-359) | PDK1 | PDK1 (aa 51-359) | PDPK1 | PDPK1_HUMAN | hPDK1
Type:Enzyme Catalytic Domain
Mol. Mass.:35302.26
Organism:Homo sapiens (Human)
Description:O15530[51-359]
Residue:309
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM17054
PDKtide
Name:PDKtide
Synonyms:Synthetic PDK substrate peptide
Type:Peptide
Mol. Mass.:4766.24
Organism:n/a
Description:n/a
Residue:39
Sequence:
KTFCGTPEYLAPEVRREPRILSEEEQEMFRDFDYIADWC