| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM17090 |
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| Substrate/Competitor | BDBM12658 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 2.5±0.2 nM |
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| Citation |  Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors J Med Chem50:2967-80 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Coagulation factor X precursor | F10 | FA10_RAT | Factor Xa (fXa) | Stuart factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54255.03 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 482 |
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| Sequence: | MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEE
ICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKN
CELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRA
KRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKR
GECPWQALLFSDEETDGFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMV
HEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVS
GFGRTHEKGRQSKVLKMMEVPYVDRNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGP
HVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKARVGPTSETPRLTHP
PY
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| BDBM17090 |
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| BDBM12658 |
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| Name | BDBM17090 |
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| Synonyms: | 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(methylamino)methyl]thiophene-2-carboxamide | Thiophene-Anthranilamide, 10b | ZK 814048 | ZK814048 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17Cl3N4O3S |
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| Mol. Mass. | 499.798 |
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| SMILES | CNCc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl |
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| Structure | 
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