| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM17251 |
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| Substrate/Competitor | BDBM17139 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Ki | >5000±n/a nM |
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| Citation |  Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa. Bioorg Med Chem15:2127-46 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I |
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| Type: | Enzyme |
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| Mol. Mass.: | 25790.52 |
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| Organism: | Bos taurus (bovine) |
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| Description: | P00760 |
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| Residue: | 246 |
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| Sequence: | MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
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| BDBM17251 |
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| BDBM17139 |
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| Name | BDBM17251 |
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| Synonyms: | ethyl 2-({[4-chloro-5-({4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}carbamoyl)thiophen-3-yl]methyl}(methyl)amino)acetate | thiophene-containing non-amidine inhibitor, 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22Cl3N3O4S |
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| Mol. Mass. | 554.873 |
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| SMILES | CCOC(=O)CN(C)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl |
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| Structure | 
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