| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prothrombin |
|---|
| Ligand | BDBM17261 |
|---|
| Substrate/Competitor | BDBM12680 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| Ki | 310±n/a nM |
|---|
| Citation |  Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa. Bioorg Med Chem15:2127-46 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Prothrombin |
|---|
| Name: | Prothrombin |
|---|
| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 70029.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00734 |
|---|
| Residue: | 622 |
|---|
| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
|
|
|
|---|
| BDBM17261 |
|---|
| BDBM12680 |
|---|
| Name | BDBM17261 |
|---|
| Synonyms: | 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-{[methyl(1-methylpiperidin-4-yl)amino]methyl}thiophene-2-carboxamide | thiophene-containing non-amidine inhibitor, 63 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H27Cl3N4O2S |
|---|
| Mol. Mass. | 565.942 |
|---|
| SMILES | CN(Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl)C1CCN(C)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
