| Reaction Details |
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 | Report a problem with these data |
| Target | Baculoviral IAP repeat-containing protein 2 [266-354] |
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| Ligand | BDBM17344 |
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| Substrate/Competitor | BDBM17342 |
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| Meas. Tech. | Fluorescence Polarization Affinity Measurements. |
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| pH | 7.2±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 30±n/a nM |
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| Citation |  Zobel, K; Wang, L; Varfolomeev, E; Franklin, MC; Elliott, LO; Wallweber, HJ; Okawa, DC; Flygare, JA; Vucic, D; Fairbrother, WJ; Deshayes, K Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol1:525-33 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Baculoviral IAP repeat-containing protein 2 [266-354] |
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| Name: | Baculoviral IAP repeat-containing protein 2 [266-354] |
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| Synonyms: | API1 | BIRC2 | BIRC2_HUMAN | Chimeric protein of inhibitor of apoptosis protein 2-baculovirus IAP repeat 3 (BIR3) | MIHB | RNF48 | cIAP1-BIR3 | cIAP1-BIR3/XIAP-BIR3 chimeric protein | cIAP1XBIR3 |
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| Type: | Chimeric Protein |
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| Mol. Mass.: | 10496.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13490[266-354] |
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| Residue: | 89 |
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| Sequence: | MQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVE
HAKWFPRCEFLIRMKGQEFVDEIQGRYPH
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| BDBM17344 |
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| BDBM17342 |
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| Name | BDBM17344 |
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| Synonyms: | (2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanoic acid | AVPW | L-alanyl-L-valyl-L-prolyl-L-tryptophan |
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| Type | Polypeptide |
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| Emp. Form. | C24H33N5O5 |
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| Mol. Mass. | 471.5493 |
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| SMILES | CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r| |
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| Structure | 
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