| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 [44-750] |
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| Ligand | BDBM17662 |
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| Substrate/Competitor | BDBM17658 |
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| Meas. Tech. | Determination of Inhibition Concentration Values (IC50) |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | >10000000±n/a nM |
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| Comments | Result is taken from Brain Res. 1986, 385, 205-211. |
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| Citation |  Barinka, C; Rovenská, M; Mlcochová, P; Hlouchová, K; Plechanovová, A; Majer, P; Tsukamoto, T; Slusher, BS; Konvalinka, J; Lubkowski, J Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. J Med Chem50:3267-73 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Glutamate carboxypeptidase 2 [44-750] |
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| Name: | Glutamate carboxypeptidase 2 [44-750] |
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| Synonyms: | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate Carboxypeptidase II (GCPII) | Glutamate carboxypeptidase 2 | Membrane glutamate carboxypeptidase | NAALAD1 | PSM | PSMA | Prostate-specific membrane antigen | Prostate-specific membrane antigen (PSMA) | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
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| Type: | Enzyme |
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| Mol. Mass.: | 79524.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The extracellular domain of human glutamate carboxypeptidase II (rhGCPII, amino acids 44-750) was overexpressed in Drosophila Schneider S2 cells and purified to homogeneity. |
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| Residue: | 707 |
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| Sequence: | KSSNEATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEF
GLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSA
FSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAK
GVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGI
AEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVK
MHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFG
TLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLR
VDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEV
FFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGM
VFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIA
SKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGE
SFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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| BDBM17662 |
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| BDBM17658 |
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| Name | BDBM17662 |
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| Synonyms: | (2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoic acid | 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid | AMPA | CHEMBL276815 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H10N2O4 |
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| Mol. Mass. | 186.1653 |
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| SMILES | Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O |
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| Structure | 
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