| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
|---|
| Ligand | BDBM189773 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay |
|---|
| Ki | <0.010±n/a nM |
|---|
| Citation |  Catron, N; Lindley, D; Miller, JM; Schmitt, EA; Tong, P Solid dispersions containing an apoptosis-inducing agent US Patent US10213433 Publication Date 2/26/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Apoptosis regulator Bcl-2 |
|---|
| Name: | Apoptosis regulator Bcl-2 |
|---|
| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
|---|
| Type: | Homodimer or heterodimer |
|---|
| Mol. Mass.: | 26269.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10415 |
|---|
| Residue: | 239 |
|---|
| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
|
|
|
|---|
| BDBM189773 |
|---|
| n/a |
|---|
| Name | BDBM189773 |
|---|
| Synonyms: | US10213433, Compound 345 | US11369599, Compound 345 | US20240043404, Example 345 | US9174982, 345 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C47H50Cl2FN7O6S |
|---|
| Mol. Mass. | 930.913 |
|---|
| SMILES | FC1(COc2ncc(cc2Cl)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC4(CC4)CC3)c3ccc(Cl)cc3)CC2)CCN(CC1)C1COC1 |t:42| |
|---|
| Structure | 
|
|---|
Search and Browse
