Reaction Details |
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Target | Monocarboxylate transporter 4 |
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Ligand | BDBM345264 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Lactate Transport in MCT4-Expressing MDA-MB-453 Breast Cancer Cells |
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IC50 | 21.0±n/a nM |
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Citation | Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent US10214492 Publication Date 2/26/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Monocarboxylate transporter 4 |
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Name: | Monocarboxylate transporter 4 |
Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 |
Type: | PROTEIN |
Mol. Mass.: | 49474.36 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_104604 |
Residue: | 465 |
Sequence: | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
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BDBM345264 |
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n/a |
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Name | BDBM345264 |
Synonyms: | 2-[[5-(3-Chlorophenyl)-1-[(2- chlorophenyl)methyl]pyrazol-3- yl]methoxy]-2-methyl-propanoic acid 1H NMR (CD3OD, 400 MHz) $#948; 1.32 (S, 6h) 4.58 (s, 2H), 5.42 (s, 2H), 6.57 (s, 1H), 6.67-6.80 (m, 1H), 7.22-7.30 (m, 3H), 7.32-42 (m, 4H). | US10202350, Example 10 | US10214492, Example 10 | US11292767, Example 10 | US11724989, Example 10 |
Type | Small organic molecule |
Emp. Form. | C21H20Cl2N2O3 |
Mol. Mass. | 419.301 |
SMILES | CC(C)(OCc1cc(-c2cccc(Cl)c2)n(Cc2ccccc2Cl)n1)C(O)=O |
Structure |
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