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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Monocarboxylate transporter 4 | ||
| Ligand | BDBM345280 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells | ||
| IC50 | 9.40±n/a nM | ||
| Citation |  Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent US10214492 Publication Date 2/26/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Monocarboxylate transporter 4 | |||
| Name: | Monocarboxylate transporter 4 | ||
| Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 49474.36 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_104604 | ||
| Residue: | 465 | ||
| Sequence: |
| ||
| BDBM345280 | |||
| n/a | |||
| Name | BDBM345280 | ||
| Synonyms: | 2-[[1-[(2-Fluorophenyl)methyl]-5-(3- isobutoxyphenyl)pyrazol-3-yl]methoxy]-2- methyl-propanoic acid 1HNMR (CDCl3): $#948; 0.97 (s, 3H), 0.99 (s, 3H), 1.55 (s, 6H), 2.00-2.06 (m, 1H), 3.70 (d, 2H), 4.62 (s, 2H), 5.39 (s, 2H), 6.37 (s, 1H), 6.79-6.80 (m, 1H), 6.87-7.09 (M, 5H), 7.22-7.30 (m, 2H) | US10202350, Example 26 | US10214492, Example 26 | US11292767, Example 26 | US11724989, Example 26 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H29FN2O4 | ||
| Mol. Mass. | 440.5072 | ||
| SMILES | CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1F | ||
| Structure | 
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