| Reaction Details |
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 | Report a problem with these data |
| Target | Period circadian protein homolog 2 |
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| Ligand | BDBM356697 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Per2 Assay |
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| EC50 | 833±n/a nM |
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| Citation |  Bersot, R; Humphries, P Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators US Patent US10214507 Publication Date 2/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Period circadian protein homolog 2 |
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| Name: | Period circadian protein homolog 2 |
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| Synonyms: | Circadian clock protein PERIOD 2 | KIAA0347 | PER2 | PER2_HUMAN | Period circadian protein homolog 2 | hPER2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 136576.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116705 |
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| Residue: | 1255 |
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| Sequence: | MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDD
SGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKELIKTLKELKV
HLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEEMES
VTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFH
SFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSVRKSHENEIRYHPFRMTPYLVKVRD
QQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQD
LIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINP
WSRKISFIIGRHKVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSS
GYGSLGSNGSHEHLMSQTSSSDSNGHEDSRRRRAEICKNGNKTKNRSHYSHESGEQKKKS
VTEMQTNPPAEKKAVPAMEKDSLGVSFPEELACKNQPTCSYQQISCLDSVIRYLESCNEA
ATLKRKCEFPANVPALRSSDKRKATVSPGPHAGEAEPPSRVNSRTGVGTHLTSLALPGKA
ESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDCLAGPALACGLSQEKEPF
KKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKGQPSERTAPGLRN
TSGIDSPWKKTGKNRKLKSKRVKPRDSSESTGSGGPVSARPPLVGLNATAWSPSDTSQSS
CPAVPFPAPVPAAYSLPVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQPPPFPAPL
APVMAFMLPSYSFPSGTPNLPQAFFPSQPQFPSHPTLTSEMASASQPEFPSRTSIPRQPC
ACPATRATPPSAMGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTGATETAAVGA
DCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASESLGSG
SLGCDASPSGAGSSDTSHTSKYFGSIDSSENNHKAKMNTGMEESEHFIKCVLQDPIWLLM
ADADSSVMMTYQLPSRNLEAVLKEDREKLKLLQKLQPRFTESQKQELREVHQWMQTGGLP
AAIDVAECVYCENKEKGNICIPYEEDIPSLGLSEVSDTKEDENGSPLNHRIEEQT
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| BDBM356697 |
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| n/a |
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| Name | BDBM356697 |
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| Synonyms: | 1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypropyl)-3,5- dimethyltetrahydro- pyrimidin-2(1H)- one | US10214507, Compound 94 | US10759777, Compound 94 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F2N3O2 |
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| Mol. Mass. | 387.423 |
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| SMILES | CC1CN(C)C(=O)N(CC(O)Cn2c3ccc(F)cc3c3cc(F)ccc23)C1 |
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| Structure | 
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