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TargetRenin
LigandBDBM18005
Substrate/CompetitorGreen Flourescent Protein (tGFP)
Meas. Tech.In Vitro Renin IC50 Determinations (Tandem GFP FRET Assay)
IC50 2±n/a nM
Citation Powell, NA; Ciske, FL; Cai, C; Holsworth, DD; Mennen, K; Van Huis, CA; Jalaie, M; Day, J; Mastronardi, M; McConnell, P; Mochalkin, I; Zhang, E; Ryan, MJ; Bryant, J; Collard, W; Ferreira, S; Gu, C; Collins, R; Edmunds, JJ Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors. Bioorg Med Chem15:5912-49 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM18005
Green Flourescent Protein (tGFP)
Name:Green Flourescent Protein (tGFP)
Synonyms:n/a
Type:Other Protein Type
Mol. Mass.:358.43
Organism:n/a
Description:The tGFP substrate contained a nine amino acid (Ile-His-Pro-Phe-His-Leu-Val-Ile-His) recognition sequence for human renin flanked by two GPF proteins (W1B and Topaz).
Residue:3
Sequence:
n/a