Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM18043 |
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Substrate/Competitor | BDBM18044 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 6.4±n/a |
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Temperature | 303.15±n/a K |
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IC50 | 4±n/a nM |
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Citation | Whitlow, M; Howard, AJ; Stewart, D; Hardman, KD; Chan, JH; Baccanari, DP; Tansik, RL; Hong, JS; Kuyper, LF X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor. J Med Chem44:2928-32 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DFR1 | DYR_CANAX | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 22141.77 |
Organism: | Candida albicans |
Description: | C. albicans DHFR was expressed in E. coli BL21, and purified to homogeneity. |
Residue: | 192 |
Sequence: | MSKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWE
SIPQKFRPLPDRLNIILSRSYENKIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNE
LINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQPKSELQKFVGDTVLEDDIKEG
DFTYNYTLWTRK
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BDBM18043 |
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BDBM18044 |
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Name | BDBM18043 |
Synonyms: | 1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QUINAZOLINE | 5-(pentan-3-yl)-5,10,12-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),2(6),3,7,9,11-hexaene-11,13-diamine | CHEMBL318721 | GW345 |
Type | Small organic molecule |
Emp. Form. | C15H19N5 |
Mol. Mass. | 269.3449 |
SMILES | CCC(CC)n1ccc2c1ccc1nc(N)nc(N)c21 |
Structure |
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