Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Ligand | BDBM165922 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | The [3H]-methyllycaconitine binding assay | ||
| Ki | 24.0±n/a nM | ||
| Citation |  Luithle, J; Böβ, F; Erb, C; Hafner, F; Schnizler, K; Flessner, T; Van Kampen, M; Van Der Staay, F 2-heteroaryl carboxamides US Patent US10214524 Publication Date 2/26/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuronal acetylcholine receptor subunit alpha-7 | |||
| Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56502.44 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q05941 | ||
| Residue: | 502 | ||
| Sequence: |
| ||
| BDBM165922 | |||
| n/a | |||
| Name | BDBM165922 | ||
| Synonyms: | US10214524, Example 4 | US9067931, 4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H29N3O3 | ||
| Mol. Mass. | 431.5268 | ||
| SMILES | O=C(N[C@H]1CN2CCC1CC2)c1cc2ccc(cc2o1)-c1ccc(cc1)N1CCOCC1 |r,wU:3.2,(-4.99,-2.36,;-4.99,-.82,;-6.33,-.05,;-7.66,-.82,;-7.66,-2.36,;-8.99,-3.13,;-10.33,-2.36,;-10.33,-.82,;-8.99,-.05,;-8.22,-1.39,;-9.71,-1.79,;-3.66,-.05,;-3.5,1.48,;-1.99,1.8,;-1.22,3.13,;.32,3.13,;1.09,1.8,;.32,.47,;-1.22,.47,;-2.25,-.68,;2.63,1.8,;3.4,.47,;4.94,.47,;5.71,1.8,;4.94,3.13,;3.4,3.13,;7.25,1.8,;8.02,.47,;9.56,.47,;10.33,1.8,;9.56,3.13,;8.02,3.13,)| | ||
| Structure | 
| ||