| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucocorticoid receptor |
|---|
| Ligand | BDBM18705 |
|---|
| Substrate/Competitor | BDBM18207 |
|---|
| Meas. Tech. | Fluorescence Polarization Competitive Binding Assay. |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| IC50 | 360±n/a nM |
|---|
| Citation |  Takahashi, H; Bekkali, Y; Capolino, AJ; Gilmore, T; Goldrick, SE; Kaplita, PV; Liu, L; Nelson, RM; Terenzio, D; Wang, J; Zuvela-Jelaska, L; Proudfoot, J; Nabozny, G; Thomson, D Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists. Bioorg Med Chem Lett17:5091-5 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Glucocorticoid receptor |
|---|
| Name: | Glucocorticoid receptor |
|---|
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 85656.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04150 |
|---|
| Residue: | 777 |
|---|
| Sequence: | MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
|
|
|
|---|
| BDBM18705 |
|---|
| BDBM18207 |
|---|
| Name | BDBM18705 |
|---|
| Synonyms: | 6-(2-methoxyphenyl)-2,2-dimethyl-4-[(prop-2-en-1-ylsulfanyl)methyl]-1,2-dihydroquinoline | dihydroquinoline compound, 16 | dihydroquinoline-based ligand, 13 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25NOS |
|---|
| Mol. Mass. | 351.505 |
|---|
| SMILES | COc1ccccc1-c1ccc2NC(C)(C)C=C(CSCC=C)c2c1 |t:17| |
|---|
| Structure | 
|
|---|
Search and Browse
