| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N] |
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| Ligand | BDBM18783 |
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| Substrate/Competitor | BDBM18044 |
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| Meas. Tech. | Inhibitor Screening Using Bacterial System (IC50) and Measurement of Inhibition Constant (Ki) |
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| Ki | 1.05±n/a nM |
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| IC50 | 10450±n/a nM |
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| Citation |  Bunyarataphan, S; Leartsakulpanich, U; Taweechai, S; Tarnchompoo, B; Kamchonwongpaisan, S; Yuthavong, Y Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays. Antimicrob Agents Chemother50:3631-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N] |
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| Name: | Bifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N] |
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| Synonyms: | DRTS_PLAVI | Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Muatnt (S58R/S117N) | Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Mutant SP21 |
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| Type: | Enzyme |
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| Mol. Mass.: | 27235.37 |
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| Organism: | Plasmodium vivax (malaria parasite P. vivax) |
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| Description: | O02604[1-238,S58R,S117N] |
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| Residue: | 238 |
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| Sequence: | MENLSDVFDIYAICACCKVAPTSEGTKNEPFSPRTFRGLGNKGTLPWKCNSVDMKYFRSV
TTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSNWES
IPKQYKPLPNRINVVLSKTLTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYR
ECLSRNLIKQIYFTRINGAYPCDVFFPEFDESEFRVTSVSEVYNSKGTTLDFLVYSKV
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| BDBM18783 |
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| BDBM18044 |
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| Name | BDBM18783 |
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| Synonyms: | 5-(3,4-dichlorophenyl)-6-ethylpyrimidine-2,4-diamine | CHEMBL21799 | P13 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12Cl2N4 |
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| Mol. Mass. | 283.156 |
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| SMILES | CCc1nc(N)nc(N)c1-c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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