| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor beta |
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| Ligand | BDBM18916 |
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| Substrate/Competitor | BDBM18860 |
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| Meas. Tech. | TRbeta-Binding Assay |
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| pH | 7±n/a |
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| Temperature | 277.15±n/a K |
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| IC50 | 4.3±n/a nM |
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| Citation |  Li, YL; Litten, C; Koehler, KF; Mellström, K; Garg, N; Garcia Collazo, AM; Färnegård, M; Grynfarb, M; Husman, B; Sandberg, J; Malm, J Thyroid receptor ligands. Part 4: 4'-amido bioisosteric ligands selective for the thyroid hormone receptor beta. Bioorg Med Chem Lett16:884-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Thyroid hormone receptor beta |
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| Name: | Thyroid hormone receptor beta |
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| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
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| Type: | Receptor |
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| Mol. Mass.: | 52793.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
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| Residue: | 461 |
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| Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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| BDBM18916 |
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| BDBM18860 |
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| Name | BDBM18916 |
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| Synonyms: | 2-{4-[3-bromo-4-(2-methylbutanamido)phenoxy]-3,5-dichlorophenyl}acetic acid | 4-amido bioisosteric ligand, 12c |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18BrCl2NO4 |
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| Mol. Mass. | 475.161 |
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| SMILES | CCC(C)C(=O)Nc1ccc(Oc2c(Cl)cc(CC(O)=O)cc2Cl)cc1Br |
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| Structure | 
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