| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM360515 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity Assay |
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| IC50 | 3886±n/a nM |
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| Citation |  Imbriglio, J; London, C; Lu, Z; Tata, J; Xiong, Y; You, M; Youm, H Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US9828369 Publication Date 11/28/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM360515 |
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| n/a |
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| Name | BDBM360515 |
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| Synonyms: | N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-5-phenyl-1,2,4- oxadiazole-3-carboxamide | US9828369, Example 72 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20N4O3 |
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| Mol. Mass. | 436.462 |
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| SMILES | COc1cccc(c1)-c1ccc(CNC(=O)c2noc(n2)-c2ccccc2)c2cnccc12 |
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| Structure | 
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