Reaction Details |
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Target | Diacylglycerol O-acyltransferase 2 |
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Ligand | BDBM360517 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Activity Assay |
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IC50 | 1271±n/a nM |
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Citation | Imbriglio, J; London, C; Lu, Z; Tata, J; Xiong, Y; You, M; Youm, H Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US9828369 Publication Date 11/28/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol O-acyltransferase 2 |
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Name: | Diacylglycerol O-acyltransferase 2 |
Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 43848.90 |
Organism: | Homo sapiens (Human) |
Description: | Q96PD7 |
Residue: | 388 |
Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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BDBM360517 |
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n/a |
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Name | BDBM360517 |
Synonyms: | N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-1-phenyl-1H-pyrazole-3- carboxamide | US9828369, Example 74 |
Type | Small organic molecule |
Emp. Form. | C27H22N4O2 |
Mol. Mass. | 434.4892 |
SMILES | COc1cccc(c1)-c1ccc(CNC(=O)c2ccn(n2)-c2ccccc2)c2cnccc12 |
Structure |
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