Reaction Details |
| Report a problem with these data |
Target | Cytosolic arginine sensor for mTORC1 subunit 1 |
---|
Ligand | BDBM315536 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Inhibition Assay |
---|
IC50 | <25±n/a nM |
---|
Citation | Ren, P; Liu, Y; Li, L; Chan, K; Wilson, TE Kinase inhibitors and methods of use US Patent US9828378 Publication Date 11/28/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytosolic arginine sensor for mTORC1 subunit 1 |
---|
Name: | Cytosolic arginine sensor for mTORC1 subunit 1 |
Synonyms: | CAST1_HUMAN | CASTOR1 | Cellular arginine sensor for mTORC1 protein 1 | GATS-like protein 3 | GATSL3 | mTORC1 protein 1 |
Type: | Protein |
Mol. Mass.: | 36264.36 |
Organism: | Homo sapiens (Human) |
Description: | Q8WTX7 |
Residue: | 329 |
Sequence: | MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGF
KELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQT
DFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSP
QNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIV
MDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYIST
FNFDHALVPEDGIGSVIEVLQRRQEGLAS
|
|
|
BDBM315536 |
---|
n/a |
---|
Name | BDBM315536 |
Synonyms: | US10172858, Table 2.31 | US9828378, # 31 |
Type | Small organic molecule |
Emp. Form. | C22H23N7O2 |
Mol. Mass. | 417.4637 |
SMILES | Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCN(CC1)C(=O)C1CC1 |
Structure |
|