| Reaction Details |
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 | Report a problem with these data |
| Target | Cytosolic arginine sensor for mTORC1 subunit 1 |
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| Ligand | BDBM315536 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | <25±n/a nM |
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| Citation |  Ren, P; Liu, Y; Li, L; Chan, K; Wilson, TE Kinase inhibitors and methods of use US Patent US9828378 Publication Date 11/28/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytosolic arginine sensor for mTORC1 subunit 1 |
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| Name: | Cytosolic arginine sensor for mTORC1 subunit 1 |
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| Synonyms: | CAST1_HUMAN | CASTOR1 | Cellular arginine sensor for mTORC1 protein 1 | GATS-like protein 3 | GATSL3 | mTORC1 protein 1 |
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| Type: | Protein |
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| Mol. Mass.: | 36264.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8WTX7 |
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| Residue: | 329 |
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| Sequence: | MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGF
KELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQT
DFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSP
QNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIV
MDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYIST
FNFDHALVPEDGIGSVIEVLQRRQEGLAS
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| BDBM315536 |
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| n/a |
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| Name | BDBM315536 |
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| Synonyms: | US10172858, Table 2.31 | US9828378, # 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N7O2 |
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| Mol. Mass. | 417.4637 |
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| SMILES | Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCN(CC1)C(=O)C1CC1 |
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| Structure | 
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