| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 6 |
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| Ligand | BDBM19155 |
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| Substrate/Competitor | BDBM19150 |
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| Meas. Tech. | HDAC Enzyme Activity Assay |
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| pH | 8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | >10000±n/a nM |
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| Comments | MCF7 cells growth inhibition, IC50=55 +/- 11 nM.HeLa nuclear HDACs inhibition, IC50=242 nM. |
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| Citation |  Yurek-George, A; Cecil, AR; Mo, AH; Wen, S; Rogers, H; Habens, F; Maeda, S; Yoshida, M; Packham, G; Ganesan, A The First Biologically Active Synthetic Analogues of FK228, the Depsipeptide Histone Deacetylase Inhibitor. J Med Chem50:5720-5726 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Histone deacetylase 6 |
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| Name: | Histone deacetylase 6 |
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| Synonyms: | HD6 | HDAC6_MOUSE | Hdac6 | Histone Deacetylase 6 (HDAC6) | Histone deacetylase | Histone deacetylase mHDA2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 125762.28 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1460074 |
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| Residue: | 1149 |
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| Sequence: | MTSTGQDSSTRQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNLAEVKKKGKMKKLSQ
PAEEDLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPESPERLHAIREQLIL
EGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAETYDSVYLHPNSY
SCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCMFNHLAVAARYAQKK
HRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTIGFGQGQ
GYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDALHGDPKGEMAATPA
GFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLGDPCPMLESCVVPCASAQ
TSIYCTLEALEPFWEVLERSVETQEEDEVEEAVLEEEEEEGGWEATALPMDTWPLLQNRT
GLVYDEKMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHS
AEYVEHLRTTEKMKTRDLHREGANFDSIYICPSTFACAKLATGAACRLVEAVLSGEVLNG
IAVVRPPGHHAEPNAACGFCFFNSVAVAARHAQIIAGRALRILIVDWDVHHGNGTQHIFE
DDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHR
LVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGG
YNLASISESMAACTHSLLGDPPPQLTLLRPPQSGALVSISEVIQVHRKYWRSLRLMKMED
KEECSSSRLVIKKLPPTASPVSAKEMTTPKGKVPEESVRKTIAALPGKESTLGQAKSKMA
KAVLAQGQSSEQAAKGTTLDLATSKETVGGATTDLWASAAAPENFPNQTTSVEALGETEP
TPPASHTNKQTTGASPLQGVTAQQSLQLGVLSTLELSREAEEAHDSEEGLLGEAAGGQDM
NSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGTVQENWVCL
TCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYVCQAYVHHEDLQDVKNAAHQNK
FGEDMPHSH
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| BDBM19155 |
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| BDBM19150 |
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| Name | BDBM19155 |
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| Synonyms: | (6R,9S,12R,16R)-16-[(1E)-4-(acetylsulfanyl)but-1-en-1-yl]-9,12-dimethyl-6-(propan-2-yl)-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentone | FK228 Analogue, 15b |
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| Type | Small organic molecule |
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| Emp. Form. | C22H34N4O7S |
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| Mol. Mass. | 498.593 |
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| SMILES | CC(C)[C@H]1NC(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)C[C@@H](OC(=O)CNC1=O)\C=C\CCSC(C)=O |r| |
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| Structure | 
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