| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase 1 |
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| Ligand | BDBM19253 |
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| Substrate/Competitor | BDBM19254 |
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| Meas. Tech. | IMPDH Type 1 Enzyme Assay |
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| pH | 8±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 110±n/a nM |
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| Comments | K562 cell proliferation, IC50=12.4 uM. |
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| Citation |  Chen, L; Gao, G; Felczak, K; Bonnac, L; Patterson, SE; Wilson, D; Bennett, EM; Jayaram, HN; Hedstrom, L; Pankiewicz, KW Probing Binding Requirements of Type I and Type II Isoforms of Inosine Monophosphate Dehydrogenase with Adenine-Modified Nicotinamide Adenine Dinucleotide Analogues. J Med Chem50:5743-5751 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase 1 |
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| Name: | Inosine-5'-monophosphate dehydrogenase 1 |
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| Synonyms: | IMDH1_HUMAN | IMP dehydrogenase 1 | IMPD 1 | IMPD1 | IMPDH-I | IMPDH1 | Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55407.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant IMPDH1 expressed in E. coli. |
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| Residue: | 514 |
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| Sequence: | MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV
LSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMT
PRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDS
QKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR
SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
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| BDBM19253 |
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| BDBM19254 |
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| Name | BDBM19253 |
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| Synonyms: | CHEMBL394276 | NSC 358285 | Tiazofurin Adenine Dinucleotide (TAD) | [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]hydrogen phosphate | [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid | tiazofurin adenine dinucleotide |
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| Type | Nucleoside or nucleotide |
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| Emp. Form. | C19H25N7O14P2S |
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| Mol. Mass. | 669.453 |
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| SMILES | NC(=O)c1csc(n1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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