Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM19558 |
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Substrate/Competitor | BDBM19583 |
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Meas. Tech. | Enzyme Inhibition Assay |
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Ki | >100000±n/a nM |
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Citation | Liu, H; Tully, DC; Epple, R; Bursulaya, B; Li, J; Harris, JL; Williams, JA; Russo, R; Tumanut, C; Roberts, MJ; Alper, PB; He, Y; Karanewsky, DS Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1. Bioorg Med Chem Lett15:4979-84 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM19558 |
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BDBM19583 |
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Name | BDBM19558 |
Synonyms: | (2S)-3-(4-methoxyphenyl)-N-{2-[(4-methoxyphenyl)amino]ethyl}-2-[(3-methylphenyl)formamido]propanamide | arylaminoethyl amide, 5l |
Type | Small organic molecule |
Emp. Form. | C27H31N3O4 |
Mol. Mass. | 461.5527 |
SMILES | COc1ccc(C[C@H](NC(=O)c2cccc(C)c2)C(=O)NCCNc2ccc(OC)cc2)cc1 |r| |
Structure |
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