| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
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| Ligand | BDBM135823 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 39.0±n/a nM |
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| Citation |  Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors US Patent US9833457 Publication Date 12/5/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
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| Name: | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
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| Synonyms: | DPDE4 | PDE4B | PDE4B2 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) | phosphodiesterase 4B2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 64320.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07343-2 |
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| Residue: | 564 |
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| Sequence: | MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQ
LETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPT
QKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI
FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA
DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM
VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY
QSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVID
PENRDSLGETDIDIATEDKSPVDT
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| BDBM135823 |
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| n/a |
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| Name | BDBM135823 |
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| Synonyms: | US10085990, Example 122 | US10568888, Example 122 | US8853226, 122 | US9393245, 122 | US9833457, 122 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25ClN4O7S2 |
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| Mol. Mass. | 593.072 |
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| SMILES | COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)CS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |
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| Structure | 
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