| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
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| Ligand | BDBM50054405 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PTP Assay |
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| IC50 | 660±30 nM |
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| Citation |  Zhang, Z; Kontaridis, M; Zeng, L; Wang, J SHP2 inhibitors and methods of treating autoimmune and/or glomerulonephritis-associated diseases using SHP2 inhibitors US Patent US9844535 Publication Date 12/19/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
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| Name: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
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| Synonyms: | INPPL-1 | INPPL1 | Inositol polyphosphate phosphatase-like protein 1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | Protein 51C | SH2 domain-containing inositol phosphatase 2 | SHIP-2 | SHIP2 | SHIP2_HUMAN | Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 138596.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15357 |
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| Residue: | 1258 |
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| Sequence: | MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS
SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS
TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT
HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE
PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE
WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN
KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT
HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT
YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP
VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS
FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA
LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS
KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR
LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT
VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR
GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP
ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG
MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
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| BDBM50054405 |
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| n/a |
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| Name | BDBM50054405 |
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| Synonyms: | CHEMBL3319358 | US9522881, 11a-3 (L97M50) | US9844535, ID 11a-3 (L97M50) |
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| Type | Small organic molecule |
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| Emp. Form. | C31H23ClIN3O6 |
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| Mol. Mass. | 695.888 |
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| SMILES | Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(OCc3ccccc3)c(Cl)c2)c1 |
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| Structure | 
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