| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM143749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding Assay |
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| Ki | 18.0±n/a nM |
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| Citation |  Gelin, CF; Lebold, TP; Shireman, BT Substituted 2-azabicycles and their use as orexin receptor modulators US Patent US9845333 Publication Date 12/19/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
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| Type: | Protein |
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| Mol. Mass.: | 46817.55 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P56718 |
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| Residue: | 416 |
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| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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| BDBM143749 |
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| n/a |
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| Name | BDBM143749 |
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| Synonyms: | US10183953, Example 10 | US8969352, 10 | US9611277, Example 10 | US9845333, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22F3N3O3 |
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| Mol. Mass. | 457.445 |
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| SMILES | CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32| |
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| Structure | 
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