| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 2 [11-552] |
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| Ligand | BDBM362925 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 1100±n/a nM |
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| Citation |  Glick, GD 1,4-benzodiazepone-2,5-diones and related compounds with therapeutic properties US Patent US9849138 Publication Date 12/26/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Rho-associated protein kinase 2 [11-552] |
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| Name: | Rho-associated protein kinase 2 [11-552] |
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| Synonyms: | KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho kinase 2 (ROCKII) | Rho-associated protein kinase 2 |
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| Type: | Protein |
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| Mol. Mass.: | 62268.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Chemicon #14-451 |
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| Residue: | 542 |
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| Sequence: | PGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDN
FLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIK
RSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKW
AKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTA
VGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHK
NSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAP
VVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRE
TDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITL
RKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNS
QI
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|
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| BDBM362925 |
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| n/a |
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| Name | BDBM362925 |
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| Synonyms: | US9849138, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18ClN3O2 |
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| Mol. Mass. | 391.85 |
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| SMILES | CN1c2ccc(Cl)cc2C(=O)NC(Cc2ccc(cc2)-c2ccncc2)C1=O |
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| Structure | 
|
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