| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 [17-535] |
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| Ligand | BDBM362930 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | >10000000±n/a nM |
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| Citation |  Glick, GD 1,4-benzodiazepone-2,5-diones and related compounds with therapeutic properties US Patent US9849138 Publication Date 12/26/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Rho-associated protein kinase 1 [17-535] |
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| Name: | Rho-associated protein kinase 1 [17-535] |
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| Synonyms: | ROCK1 | ROCK1_HUMAN | Rho GDP-dissociation inhibitor 1 | Rho Kinase 1 | Rho-associated protein kinase 1 (ROCK1) |
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| Type: | Protien |
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| Mol. Mass.: | 60345.48 |
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| Organism: | Homo Sapiens (Human) |
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| Description: | aa 17-535 |
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| Residue: | 519 |
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| Sequence: | LLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY
EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWV
VQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIH
RDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG
RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAF
LTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKG
EEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE
EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRIN
EYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
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| BDBM362930 |
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| n/a |
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| Name | BDBM362930 |
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| Synonyms: | US9849138, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N3O2 |
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| Mol. Mass. | 357.4052 |
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| SMILES | CN1c2ccccc2C(=O)NC(Cc2ccc(cc2)-c2ccncc2)C1=O |
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| Structure | 
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