Reaction Details |
| Report a problem with these data |
Target | Procathepsin L |
---|
Ligand | BDBM19854 |
---|
Substrate/Competitor | BDBM19480 |
---|
Meas. Tech. | Enzyme Inhibition Assay and Whole Cell Enzyme Occupancy Assay |
---|
pH | 5.5±n/a |
---|
Temperature | 295.15±n/a K |
---|
IC50 | 6300±1500 nM |
---|
EC50 | 340±35 nM |
---|
Citation | Falgueyret, JP; Desmarais, S; Oballa, R; Black, WC; Cromlish, W; Khougaz, K; Lamontagne, S; Massé, F; Riendeau, D; Toulmond, S; Percival, MD Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J Med Chem48:7535-43 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Procathepsin L |
---|
Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
|
|
|
BDBM19854 |
---|
BDBM19480 |
---|
Name | BDBM19854 |
Synonyms: | CHEMBL426819 | CRA-013783/L-006235 | N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | basic piperazine-containing compound, 1 |
Type | Small organic molecule |
Emp. Form. | C24H30N6O2S |
Mol. Mass. | 466.599 |
SMILES | CN1CCN(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N |
Structure |
|