| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM19859 |
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| Substrate/Competitor | BDBM19480 |
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| Meas. Tech. | Enzyme Inhibition Assay and Whole Cell Enzyme Occupancy Assay |
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| pH | 5.5±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 55±11 nM |
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| EC50 | 230±180 nM |
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| Citation |  Falgueyret, JP; Desmarais, S; Oballa, R; Black, WC; Cromlish, W; Khougaz, K; Lamontagne, S; Massé, F; Riendeau, D; Toulmond, S; Percival, MD Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J Med Chem48:7535-43 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM19859 |
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| BDBM19480 |
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| Name | BDBM19859 |
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| Synonyms: | (2S)-N-(cyanomethyl)-3-cyclohexyl-2-(phenylformamido)propanamide | phenyl-containing analogue, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N3O2 |
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| Mol. Mass. | 313.3941 |
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| SMILES | O=C(NCC#N)[C@H](CC1CCCCC1)NC(=O)c1ccccc1 |r| |
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| Structure | 
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