| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin S |
|---|
| Ligand | BDBM19859 |
|---|
| Substrate/Competitor | BDBM19490 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| IC50 | 13±n/a nM |
|---|
| EC50 | 40±n/a nM |
|---|
| Citation |  Falgueyret, JP; Desmarais, S; Oballa, R; Black, WC; Cromlish, W; Khougaz, K; Lamontagne, S; Massé, F; Riendeau, D; Toulmond, S; Percival, MD Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J Med Chem48:7535-43 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Cathepsin S |
|---|
| Name: | Cathepsin S |
|---|
| Synonyms: | CATS_MOUSE | Cats | Ctss |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 38476.67 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | O70370 |
|---|
| Residue: | 340 |
|---|
| Sequence: | MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIW
EKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSN
RTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSN
EEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLP
FGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGK
DYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
|
|
|
|---|
| BDBM19859 |
|---|
| BDBM19490 |
|---|
| Name | BDBM19859 |
|---|
| Synonyms: | (2S)-N-(cyanomethyl)-3-cyclohexyl-2-(phenylformamido)propanamide | phenyl-containing analogue, 14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H23N3O2 |
|---|
| Mol. Mass. | 313.3941 |
|---|
| SMILES | O=C(NCC#N)[C@H](CC1CCCCC1)NC(=O)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
