| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 2 |
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| Ligand | BDBM364244 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 82.0±n/a nM |
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| Citation |  Guillo, N; Martin, V Pyrazolonaphthyridinone derivatives as MetAP2 inhibitors (methionine aminopeptidase type-2) US Patent US9856257 Publication Date 1/2/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 2 |
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| Name: | Methionine aminopeptidase 2 |
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| Synonyms: | Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67 |
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| Type: | Enzyme |
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| Mol. Mass.: | 52884.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50579 |
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| Residue: | 478 |
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| Sequence: | MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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| BDBM364244 |
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| n/a |
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| Name | BDBM364244 |
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| Synonyms: | US9856257, 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16F3N5O3S |
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| Mol. Mass. | 451.422 |
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| SMILES | CN(C)S(=O)(=O)c1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1 |
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| Structure | 
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