| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor beta |
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| Ligand | BDBM20625 |
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| Substrate/Competitor | 17beta-estradiol (E2) |
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| Meas. Tech. | ER-beta Radioligand Binding Assay and ERE-Luciferase Reporter Assay. |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 9±n/a nM |
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| EC50 | 0.02±n/a nM |
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| Citation |  Schopfer, U; Schoeffter, P; Bischoff, SF; Nozulak, J; Feuerbach, D; Floersheim, P Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes. J Med Chem45:1399-401 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Estrogen receptor beta |
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| Name: | Estrogen receptor beta |
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| Synonyms: | ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta |
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| Type: | Protein |
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| Mol. Mass.: | 59238.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92731 |
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| Residue: | 530 |
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| Sequence: | MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
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| BDBM20625 |
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| 17beta-estradiol (E2) |
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| Name | BDBM20625 |
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| Synonyms: | 4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | 4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | CHEMBL411 | Diethylstilbestrol | Diethylstilbestrol (1) | Stilbestrol | Stilboestroform |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20O2 |
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| Mol. Mass. | 268.3502 |
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| SMILES | CC\C(=C(\CC)c1ccc(O)cc1)c1ccc(O)cc1 |
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| Structure | 
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