Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM366677 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| Ki | 0.170±n/a nM | ||
| Citation |  Ray, NC; Cheng, Y; Edwards, C; Goodacre, SC; Li, W; Patel, S; Cartwright, MW; Sajad, M; Yuen, P; Zak, ME Triazolopyridine compounds, compositions and methods of use thereof US Patent US9873709 Publication Date 1/23/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
| ||
| BDBM366677 | |||
| n/a | |||
| Name | BDBM366677 | ||
| Synonyms: | US9873709, Example 1-274 | [4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- piperidyl]- [1,2,4]triazolo[1,5- a]pyridin-2- yl]amino]phenyl]-(5- methyl-2,5- diazaspiro[3.4]octan- 2-yl)methanone | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H37ClN6O2 | ||
| Mol. Mass. | 585.139 | ||
| SMILES | CN1CCCC11CC(C1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cc1 |(-8.37,3.53,;-7.6,4.86,;-8.5,6.1,;-7.6,7.35,;-6.13,6.87,;-6.13,5.33,;-4.65,5.73,;-4.25,4.25,;-5.73,3.85,;-2.91,3.48,;-2.91,1.94,;-1.58,4.25,;-.25,3.48,;1.09,4.25,;1.09,5.79,;2.42,6.56,;3.76,5.79,;3.92,4.25,;5.42,3.93,;6.19,2.6,;7.73,2.6,;8.5,3.93,;7.73,5.27,;6.19,5.27,;5.16,6.41,;5.42,1.27,;3.88,1.27,;3.11,-.07,;3.88,-1.4,;2.4,-1.8,;1.31,-.71,;5.42,-1.4,;6.19,-.07,;4.28,-2.89,;3.19,-3.98,;3.59,-5.46,;5.08,-5.86,;5.48,-7.35,;6.17,-4.77,;5.77,-3.29,;-.25,6.56,;-1.58,5.79,)| | ||
| Structure | 
| ||