| Reaction Details |
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 | Report a problem with these data |
| Target | Acid ceramidase |
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| Ligand | BDBM367210 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescent-based In Vitro Assa |
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| IC50 | 91.0±10 nM |
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| Citation |  Piomelli, D; Pagliuca, C; Pizzirani, D; Bach, A; Realini, N; De Vivo, M Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments US Patent US10226452 Publication Date 3/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Acid ceramidase |
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| Name: | Acid ceramidase |
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| Synonyms: | ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 44662.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13510 |
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| Residue: | 395 |
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| Sequence: | MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
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| BDBM367210 |
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| n/a |
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| Name | BDBM367210 |
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| Synonyms: | 2-oxo-7-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole-3-carboxamide | US10226452, Example 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N2O3 |
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| Mol. Mass. | 386.4431 |
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| SMILES | O=C(NCCCCc1ccccc1)n1c2cccc(-c3ccccc3)c2oc1=O |
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| Structure | 
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