Reaction Details |
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Target | Ceramide glucosyltransferase |
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Ligand | BDBM367624 |
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Substrate/Competitor | n/a |
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Meas. Tech. | GCS Enzymatic Assay |
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IC50 | 5.5±n/a nM |
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Citation | Wang, B Glucosylceramide synthase inhibitors for the treatment of diseases US Patent US10227312 Publication Date 3/12/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Ceramide glucosyltransferase |
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Name: | Ceramide glucosyltransferase |
Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
Type: | PROTEIN |
Mol. Mass.: | 44859.25 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1435474 |
Residue: | 394 |
Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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BDBM367624 |
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n/a |
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Name | BDBM367624 |
Synonyms: | N-((1R,2R)-3-(azetidin-1-yl)-1-(4- cyclopropoxy-3-fluorophenyl)-1- hydroxypropan-2-yl)-7-(5- chlorothiophen-2-yl)-1H- benzo[d][1,2]oxazine-4-carboxamide | US10227312, Example 9 | US10759769, Example 9 |
Type | Small organic molecule |
Emp. Form. | C28H27ClFN3O4S |
Mol. Mass. | 556.048 |
SMILES | O[C@@H]([C@@H](CN1CCC1)NC(=O)C1=NOCc2cc(ccc12)-c1ccc(Cl)s1)c1ccc(OC2CC2)c(F)c1 |r,t:12| |
Structure |
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