| Reaction Details |
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 | Report a problem with these data |
| Target | Ceramide glucosyltransferase |
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| Ligand | BDBM367649 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | GCS Enzymatic Assay |
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| IC50 | 5.5±n/a nM |
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| Citation |  Wang, B Glucosylceramide synthase inhibitors for the treatment of diseases US Patent US10227312 Publication Date 3/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ceramide glucosyltransferase |
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| Name: | Ceramide glucosyltransferase |
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| Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44859.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1435474 |
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| Residue: | 394 |
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| Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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| BDBM367649 |
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| n/a |
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| Name | BDBM367649 |
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| Synonyms: | N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hydroxy-3- (pyrrolidin-1-yl)propan-2-yl)-1-methyl- 1,9-dihydro-[1,2]oxazino[4,5- g]indazole-6-carboxamide | US10227312, Example 34 | US10759769, Example 34 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30ClN5O4 |
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| Mol. Mass. | 524.011 |
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| SMILES | Cn1ncc2ccc3C(=NOCc3c12)C(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(Cl)c1 |r,c:8| |
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| Structure | 
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