| Reaction Details |
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 | Report a problem with these data |
| Target | Ceramide glucosyltransferase |
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| Ligand | BDBM367661 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | GCS Enzymatic Assay |
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| IC50 | 5.5±n/a nM |
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| Citation |  Wang, B Glucosylceramide synthase inhibitors for the treatment of diseases US Patent US10227312 Publication Date 3/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ceramide glucosyltransferase |
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| Name: | Ceramide glucosyltransferase |
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| Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44859.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1435474 |
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| Residue: | 394 |
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| Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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| BDBM367661 |
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| n/a |
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| Name | BDBM367661 |
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| Synonyms: | 2-chloro-N-((1R,2R)-1-(4- cyclopropoxy-3-fluorophenyl)-1- hydroxy-3-(pyrrolidin-1-yl)propan-2- yl)-9H-thieno[2',3':3,4]benzo[1,2- d][1,2]oxazine-6-carboxamide | US10227312, Example 47 | US10759769, Example 47 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27ClFN3O4S |
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| Mol. Mass. | 544.037 |
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| SMILES | O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1=NOCc2c1ccc1cc(Cl)sc21)c1ccc(OC2CC2)c(F)c1 |r,t:13| |
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| Structure | 
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